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Those trials compared taking rimonabant (20 milligrams a day) against a placebo. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. 5 or 1 milligram of tesofensine was double that of weight loss seen with the currently available diet drugs Acomplia (rimonabant) or Meridia (sibutramine), the researchers said. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted.
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